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Probiotic Lactobacillus rhamnosus GG prevents alveolar bone loss in a mouse model of experimental periodontitis. Gatej, S., Marino, V., Bright, R., Fitzsimmons, T., Gully, N., Zilm, P. Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer. Van Sebille, Y., Gibson, R., Wardill, H., Ball, I., Keefe, D., & Bowen, J. Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. Optimizing cancer pain management in resource-limited settings. J., Bouzid, K., Gibson, R., Gumara, Y., Hassan, A. The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity. Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines. K., Blijlevens, N., Bossi, P., Al-Dasooqi, N. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity. Experimental Biology and Medicine, 244(7), 554-564. Highlight Article: Identifying human and murine M cells in vitro. Klisuric, A., Thierry, B., Delon, L., Prestidge, C.
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Uptake of silica particulate drug carriers in an intestine-on-a-chip: towards a better in vitro model of nanoparticulate carrier and mucus interactions. C., Khatri, A., Prestidge, C., Gibson, R., Barbe, C., & Thierry, B. Cancer Chemotherapy and Pharmacology, 83(2), 217-236. Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy. Intestinal accumulation of silica particles in a rat model of dextran sulfate sodium-induced colitis. A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models. C., Gibson, R., Prestidge, C., & Thierry, B. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Diarrhea Induced by Small Molecule Tyrosine Kinase Inhibitors Compared With Chemotherapy: Potential Role of the Microbiome. Journal of the International Academy of Periodontology, 22(2), 18-27. Probiotic Lactobacillus Rhamnosus GG Protects Against P. Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment.
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Journal of Controlled Release, 343, 584-599. Mechanisms of uptake and transport of particulate formulations in the small intestine. Rachel is recognized as a skilled communicator among peers, students, business collaborators, and partners, and has been an enthusiastic advocate for Supportive Care in Cancer.ĭelon, L., Gibson, R. These efforts demonstrate her dedication to promoting supportive care knowledge and practice on a global scale. She has also been a leader in MASCC Study Group initiatives (Mucositis and Oral Care) in developing clinical practice guidelines for the management of mucositis secondary to cancer therapy, including gastrointestinal mucositis. She is a prolific researcher in this field, and has authored or co-authored over 120 journal articles (including 15 in Supportive Care in Cancer), six book chapters, and 75 abstracts presented at the MASCC Annual Meetings. Rachel works with a team of researchers from the fields of pathology, molecular biology, microbiology, and immunology, among others, in the study of toxic effects of chemotherapy on the gut microbiome of cancer patients and the development of clinically diagnosed diarrhea, a manifestation of intestinal mucositis. Rachel's main research interest is supportive care in cancer.